Selective autophagy gets more selective: Uncoupling of autophagy flux and xenophagy flux inMycobacterium tuberculosis-infected macrophages
نویسندگان
چکیده
منابع مشابه
Selective autophagy.
During the last decade it has become evident that autophagy is not simply a non-selective bulk degradation pathway for intracellular components. On the contrary, the discovery and characterization of autophagy receptors which target specific cargo for lysosomal degradation by interaction with ATG8 (autophagy-related protein 8)/LC3 (light-chain 3) has accelerated our understanding of selective a...
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1Department of Cell Biology and Institute of Biomembranes, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands 2Protein Metabolism Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan 3BioScience Center, San Diego State University, San Diego, CA 92182, USA 4Department of Biochemistry, Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo,...
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Here we report a novel regulatory mechanism for autophagy-mediated degradation of Mycobacterium tuberculosis (Mtb) and specific strategy exploited by the virulent Mtb to evade it. We show while both avirulent (H37Ra) and virulent (H37Rv) mycobacteria could readily localize to autophagosomes, their maturation into autolysosomes (flux) was significantly inhibited by the latter strain. The inhibit...
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Autophagy is an evolutionarily conserved process of cellular self-eating and is a major pathway for degradation of cytoplasmic material by the lysosomal machinery. Autophagy functions as a cellular response in nutrient starvation, but it is also associated with the removal of protein aggregates and damaged organelles and therefore plays an important role in the quality control of proteins and o...
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A t g 8 A t g 8 A t g 8 A t g 8 A t g 8 A t g 8 A t g 8 A t g 8 A t g 8 A t g 8 A t g 8 A t g 8 Atg19 A tg 1 9 prApe1 Ape1 complex
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ژورنال
عنوان ژورنال: Autophagy
سال: 2016
ISSN: 1554-8627,1554-8635
DOI: 10.1080/15548627.2016.1139263